BIOL 412
Immunology
Catalog Entry
Biology 412. Immunology
Three hours lecture (3).
Prerequisites: A grade of "C" or better in BIOL 132 and BIOL 231; or a grade of "C" or better in BIOL 111 and BIOL 112.
Provides an introduction to the science of immunology by focusing on the tissues, cells, and the mechanisms involved in the normal immune response. Emphasis is on the mechanisms of B and T cell sensitization and cellular specialization of immune cells. Active and passive immunities of the human system are considered in detail.
Detailed Description of Content of the Course
The topics covered in this course are those common to most of the textbooks available for undergraduate immunology courses. Students are first introduced to the concepts of immunology with a discussion of the major scientific discoveries that have contributed to the discipline. The structure of antigens, antibodies, and complement and their interactions are next considered. A discussion of the generation of antibody diversity is also included. Several lectures are devoted to a comparison of clinical diagnostic assays that employ antigen-antibody reactions. A lengthy examination of the immune response includes topics such as:
Once a basic understanding of the immune response is established, some of the consequences
of the immune response are examined. Students are introduced to hypersensitivity disorders,
mechanisms for rejection of transplanted tissues, immunodeficiency, and the development
of autoimmunity. The laboratory exercises allow students to observe their own immune
cells and to demonstrate immunological reactions using their own serum samples. Many
of the major immunological assays used in clinical laboratories are performed.
Detailed Description of Conduct of Course
This course is conducted primarily in a lecture format. However, students are encouraged to discuss implications of immunological concepts in class and are questioned informally in class about lecture topics. Students are required to read at least one original publication to demonstrate how scientific knowledge is gained.
Student Learning Outcomes
Other Course Information
None
Review and Approval
August 29, 2019
February 27, 2026